Dynes specializes in the literature and cultural history of Eastern European Jewry from the 18th to 21st centuries. He has a particular interest in the nexus of literature and political thought. He is currently completing a book manuscript entitled The Fiction of the State: The Polish Partitions and the Beginning of Modern Jewish Literature (1772–1848). He has also recently co-edited a special volume of Prooftexts, entitled The Beginnings of Modern Jewish Literature in Europe, with Naomi Seidman (University of Toronto). Dynes is a co-founder and organizer of the Hebrew Lab Faculty Seminar, a New-York based workgroup for scholars in Hebrew Literature.